Best damn show on television. Features the supermegafoxyawesomehot Amanda Tapping
as HBIC Dr. Helen Magnus, and is about her and her team being kick ass. The Sanctuary team also includes Will Zimmerman (the ever-pantless Robin Dunne aka Throbin Bum), Henry Foss (Ryan RyRo Robbins), Kate Freelander (Agam Darshi, the Indian goddess of I'm-freaking-gorgeous).
So basically, Magnus and the like live in this huge, fantastic, castle known as the Sanctuary. The Sanctuary is also home to what the team lovingly refer to as abnormals.
Abnormals are basically any type of creatures not found in nature or cooler versions of X-Men.