Urinating (number one) and defecating (number two) simultaneously.
Joe: Damn I got to go.
Jim: Number one or number two?
Joe: Both, bro'.. number three!
Joe Bone tarafından 8 Mart 2005, Salı
Rhyming slang for wee or pee (urinate).

Same as 'number two' is rhyming slang for poo.
Are you going to the toilet to do a number two or number three?
StephenSLR tarafından 24 Ağustos 2011, Çarşamba
Wee, pee, urinate.

Comes from the childrens nursery rhyme:

Number one, tickle my bum

Number two, do a big poo

Number three, go for a wee
Don't drink too much before bed you'll have to go number three in the middle of the night
Jaspur tarafından 29 Ekim 2011, Cumartesi
Taking a shower immediately after dropping anchor. It's called a number three because it should ALWAYS follow a number two. If you don't agree, then here is what will convince you: If you get poop on your hand and wipe it off with a dry piece of toilet paper YOUR HAND WILL STILL SMELL LIKE POOP! (shock)
Aaron Desselle always goes home from work to take a number three. His butt is clean right now.
a-diggity tarafından 29 Haziran 2004, Salı
ecstasy.

Due to a ranking of drugs. It's still in the works. All drugs have not been tried/ranked yet.

see number two
What are you doing tonight?
About to get me some of that number three.

What are they on right now?
They are hella number threed out!
Urban Dictionary tarafından 14 Kasım 2008, Cuma
The dreaded third shit of the morning, usually hits as soon as you either take a shower or leave the house.
My god that cheap draft is haunting me now! Number Three came knockin as soon as I walked out the door!

As I was drying off after a hot shower, number three hit with a vengeance not often seen in this universe and I had to dirty my clean arse....goddammitt!!
Lunicus tarafından 9 Şubat 2013, Cumartesi
Mixture of pee and poop - diharreah.
Number one - Pee
Number two - Poop
Number three - Diharreah
holymoley222 tarafından 22 Aralık 2013, Pazar
When you have extremely bad diarrhea or thin watery feces. It is often the cause of spicy food and Taco Bell.
"Hey, can we go I have to pee...?"
"Dude, don't be a fag, go in the trees."
"...from my ass."
(Number Three)
nirog tarafından 8 Ekim 2007, Pazartesi

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