Used with a hashtag (#) on Twitter to tag Twitter threesomes. Tweesome is a group of three Tweeple, F/M/F, sharing cyber sexual public Tweets i.e., engaging in group cyber sex via Twitter. Tweesome posts are properly tagged #tweesome. Often associated with #swingers.

If the number of people engaged in Twex is four or more, it is properly tagged #Tworgy. If the number of Tweeple is three and they are M/F/M, it is tagged #twangbang. If the number of people engaged is just two, it is simply Twex.
As used in a Tweet:

I'm totally up for a #tweesome! Who's naked? See my free videos at link!
twittertwat tarafından 17 Haziran 2009, Çarşamba
Top Definition
threesome involving two identical twins and another participant
"she's so hot"
"yeah man she's got a twin too"
"I'd love to have a tweesome with them"
tysseling tarafından 28 Aralık 2011, Çarşamba

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